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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: J Invest Dermatol. 2019 Mar 13;139(9):2029–2038.e3. doi: 10.1016/j.jid.2019.02.025

Figure 1. Genetic deletion of α3 in the epidermis leads to reduced Cox-2 expression and enhanced α-SMA expression in dermal cells of cutaneous wounds, in vivo.

Figure 1.

(a) Mouse wound sections (5 and 10 days post wounding) from control and α3eKO mice were immunostained for Cox-2 (brown) or α-SMA (red). E=epidermis; N=normal skin; WB=wound bed; scale bar=500μm. Wound beds were outlined (black) and defined as the ROI. Insets (red boxes) illustrate staining and wound features (scale bar=100μm). Stains were separated by a color-deconvolution algorithm, and percentages of α-SMA-positive staining (b) or Cox-2-positive staining (c) within each ROI were quantitated (ImageJ). 2-way ANOVA followed by Bonferroni post-hoc analysis, *p > 0.05, n= 4 mice per time point / genotype.