Skip to main content
. Author manuscript; available in PMC: 2020 Apr 21.
Published in final edited form as: Compr Physiol. 2019 Dec 18;10(1):21–56. doi: 10.1002/cphy.c190007

Figure 5.

Figure 5

Acute, posttranslational regulation of ASBT. Functional ASBT, which transports two Na+ ions along with one bile acid, is present in lipid rafts. Movement of ASBT out of rafts, either by the green tea catechin (−)-epigallocatechin-3-gallate (EGCG) or methyl-β-cyclodextrin (MβCD), decreases ASBT function. Activation of protein kinase C ζ (PKCζ) by phorbol 12-myristate 13-acetate (PMA) results in endocytosis and reduced function of ASBT. Similarly, activation of protein tyrosine phosphatases (PTP) by enteropathogenic Escherichia coli (EPEC) causes endocytosis of ASBT.

HHS Vulnerability Disclosure