Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Mar 16;23(3):165–177. doi: 10.1093/ijnp/pyz071

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

PMC Copyright notice

Figure 3. — Amygdala and hippocampus-based expression changes in miRNA targets across 3 comparison groups (nonlearned helplessness [NLH], learned helplessness [LH], and tested control [TC]). (a–i) All data are normalized with Gapdh and presented as the mean ± SEM. Significance level is indicated with an asterisk sign (*P ≤0.05). qPCR-based expression changes in miRNA targets Wnt3, Wnt3a, Wnt5a, Wnt5b, Wnt9b, Dvl1, Lef1, Tcf20, and Gsk3β in LH and NLH groups independently compared with TC. Expression-related significant differences in Wnt3 (P = .033), Wnt3a (P = .042), Wnt5a (P = .045), Wnt5b (P = .044), Wnt9b (P = .031), Dvl1 (P = .047), Lef1 (P = .053), and Gsk3b (P = .026) genes were noted in the LH vs the NLH group. Significant changes in expression were also noted for Wnt5b (P = .007), Tcf20 (P = .045), and Gsk3b (P = .017) genes when the NLH group was compared with the TC group. Group comparison between LH and TC rats identified significant changes in expression of Wnt3a (P = .03), Wnt5b (P = .043), Wnt9b (P = .008), Dvl1 (P = .029), and Lef1 (P = .019) genes. (j–m). All data are normalized with Gapdh and presented as the mean ± SEM. qPCR-based expression change of miRNA targets Wnt3a, Wnt5b, Dvl1, and Lef1 in hippocampus of LH and NLH groups independently compared with TC. Expression-related significant differences were only noted in Wnt3a (P < .005) gene when the LH group was compared with the TC group.