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. 2020 Apr 13;69(5):830–836. doi: 10.2337/dbi19-0012

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© 2020 by the American Diabetes Association

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Hyperpolarization of β-cells does not affect electrical activity in neighbors. Changes in β-cell membrane potential when increasing glucose from 1 to 10 mmol/L recorded under current-clamp conditions (top) and under voltage-clamp conditions when holding the membrane potential at −70 mV (middle) or −120 mV (bottom). The current oscillations reflect glucose-induced electrical activity in neighboring (unclamped) β-cells. The bottom trace appears noisier at −120 mV because of membrane breakdown (partial seal rupture) around the recording electrode at this unphysiologically negative membrane potential.