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Blockade of insulin receptor signaling is not permissive of glucagon-stimulated ketogenesis. Mice were injected with S661 (20 nmol/mouse), and glycemia (A), βOHB (B), and NEFA (C) were assessed over a 3-h period. Mice were injected with S661 (20 nmol/mouse) 1 h before injection with glucagon (20 µg/kg). Glycemia (D), βOHB (E), and NEFA (F) were assessed. Data are shown as mean ± SEM. *P < 0.05. Data were analyzed by two-way ANOVA.
