Figure 5.

Effect of diabetes, VDR^−/−, and supplemental diet on mouse corneal nerve densities. A: Representative images showing corneal subbasal nerves of 8-week diabetic duration WT, diabetic VDR^−/−, and diabetic VDR^−/− mice on the supplemental diet. B: Representative images showing corneal subbasal nerves of 12-week-old nondiabetic WT and VDR^−/− mice. C: There was no significant difference in nerve densities between WT (n = 9) and VDR^−/− (n = 10) mice or WT and diabetic WT mice (n = 7). Diabetic VDR^−/− mice (n = 6) had a significantly reduced nerve density compared with VDR^−/− or diabetic WT mice, and the supplemental diet (n = 10) did not correct this reduced nerve density. Data are mean ± SE. *P < 0.05