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. 2020 Mar 5;69(5):1052–1064. doi: 10.2337/db19-0807

Figure 4.

Figure 4

Neither ablation of MG53 nor elevation of MG53 impacts glucose hemostasis and insulin sensitivity in db/db mice. A: Body weight measurement of the four mice strains up to 32 weeks of age (WT, n = 13; mg53−/−, n = 9; db/db, n = 12; and db/db-mg53−/−, n = 6). These mice were littermates produced through crossbreeding of the db+/−mg53+/− pairs. B: GTT measurements at 18 weeks (left) and 30 weeks (right) (WT, n = 11; mg53−/−, n = 9; db/db, n = 12; and db/db-mg53−/−, n = 6). GTT of the db/db-mg53−/− mice showed a trend of reduced glucose tolerance compared with db/db littermates, but the difference did not reach statistical significance. C: ITT measurements at 20 weeks (left) and 32 weeks (right) (WT, n = 11; mg53−/−, n = 9; db/db, n = 12; and db/db-mg53−/−, n = 6). D: Quantification of AUC for the data shown in B. E: Body weight of the WT, tPA-MG53, db/db, and db/db-tPA-MG53 littermates was measured up to 32 weeks of age (WT, n = 7; tPA-MG53, n = 6; db/db, n = 7; and db/db-tPA-MG53, n = 5). F: GTT measurements at 18 weeks (left) and 30 weeks (right). G: ITT measurements at 20 weeks (left) and 32 weeks (right). Both sexes of mice were included in the experiments. H: Quantification of AUC for data shown in F.