Table 2.
Repetitive intravenous administration of rhMG53 did not alter blood metabolites in rats
| Male | Female | |||||||
|---|---|---|---|---|---|---|---|---|
| Control | 1 mg/kg rhMG53 | 10 mg/kg rhMG53 | 40 mg/kg rhMG53 | Control | 1 mg/kg rhMG53 | 10 mg/kg rhMG53 | 40 mg/kg rhMG53 | |
| Blood urea nitrogen (mg/dL) | 14.7 ± 1.5 | 14.7 ± 1.5 | 16.7 ± 1.5 | 16.0 ± 1.0 | 21.7 ± 4.0 | 22.7 ± 1.2 | 20.0 ± 3.6 | 18.7 ± 2.1 |
| Creatinine (mg/dL) | 0.190 ± 0.000 | 0.197 ± 0.021 | 0.220 ± 0.036 | 0.267 ± 0.015# | 0.327 ± 0.049 | 0.333 ± 0.042 | 0.390 ± 0.082 | 0.407 ± 0.064 |
| Glucose (mg/dL) | 175 ± 4.4 | 173.3 ± 21.9 | 192.7 ± 16.3 | 258.3 ± 33.1* | 176.7 ± 5.1 | 187.7 ± 8.6 | 184.0 ± 4.6 | 206.3 ± 6.8* |
| AST (units/L) | 84.3 ± 12.9 | 81.3 ± 6.0 | 83.7 ± 10.0 | 74.7 ± 5.1 | 81.7 ± 20.2 | 74.7 ± 4.9 | 78.0 ± 5.6 | 77.7 ± 9.0 |
| ALT (units/L) | 58.3 ± 6.7 | 59.0 ± 6.2 | 62.0 ± 15.5 | 55.7 ± 0.6 | 52.7 ± 4.0 | 46.7 ± 3.8 | 47.3 ± 4.5 | 47.0 ± 6 |
| Alkaline phosphatase (units/L) | 368.3 ± 32.0 | 352.7 ± 63.3 | 394 ± 60.4 | 325.0 ± 47.6 | 199.0 ± 7.8 | 180.0 ± 20.2 | 171.3 ± 34.6 | 187.3 ± 11.9 |
| Cholesterol (mg/dL) | 89.3 ± 7.4 | 100 ± 16.5 | 80.3 ± 7.0 | 92.0 ± 5.2 | 81.3 ± 18.9 | 80.3 ± 16.3 | 89.3 ± 22.9 | 92.3 ± 3.8 |
| Triglyceride (mg/dL) | 149.0 ± 53.7 | 103.0 ± 38.4 | 75.7 ± 34.2 | 99.0 ± 51.7 | 126.7 ± 39.8 | 80.7 ± 16.0 | 40.3 ± 5.0* | 48.3 ± 9.3* |
Data are means ± SD. Male and female rats were dosed intravenously with rhMG53 (0, 1, 10, and 40 mg/kg daily). n = 3/group. Blood metabolites at the end of the 14 days’ dosing were analyzed. ALT, alanine aminotransferase.
*
P < 0.01.
#
P < 0.05.