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. 2010 Nov 13;23(2):176–183. doi: 10.1016/j.ceb.2010.10.002

Figure 3.

Figure 3

ERAD tuning. Many ERAD regulators are short-living proteins at steady state. Some of them are degraded with the intervention of cytosolic proteasomes (e.g. SEL1L and HERP). The selective removal of EDEM1 and OS-9 from the ER can be subdivided in three steps. (1) Association with an elusive receptor allows segregation of EDEM1, OS-9 and possibly other ERAD factors (EF) from conventional, long living ER-resident chaperones (in grey); (2) the ERAD regulators exit the ER in small, LC3-I-coated vesicles, the EDEMosomes; (3) EDEMosomes deliver their content to endosomal/lysosomal compartments for disposal.