Table III.
Duration of wheezy episodes in young children in relation to various viral and bacterial triggers
| Negative |
Positive |
Results from GEE models |
||||||
|---|---|---|---|---|---|---|---|---|
| Median days (IQR) | No. of episodes | No. of children | Median days (IQR) | No. of episodes | No. of children | Unadjusted IRR (95% CI), P value (n = 483 episodes) | Confounder-adjusted IRR∗ (95% CI), P value (n = 403 episodes) | |
| Virus | ||||||||
| Picornaviruses | 10 (6-16) | 345 | 184 | 9 (6-17) | 138 | 101 | 0.91 (0.74-1.13), .40 | 0.88 (0.71-1.08), .22 |
| RSV | 9 (6-17) | 402 | 192 | 11 (7-15) | 81 | 73 | 0.94 (0.76-1.16), .54 | 0.99 (0.78-1.26), .95 |
| Coronaviruses | 10 (6-17) | 422 | 202 | 9 (5-13) | 61 | 47 | 1.04 (0.68-1.58), .85 | 1.00 (0.70-1.42), .99 |
| Other virus | 10 (6-16) | 366 | 182 | 10 (6-17) | 117 | 88 | 1.05 (0.86-1.29), .61 | 1.06 (0.87-1.30), .55 |
| Any virus | 9 (6-17) | 171 | 117 | 10 (6-17) | 312 | 171 | 0.97 (0.78-1.22), .81 | 0.95 (0.74-1.21), .67 |
| Bacteria | ||||||||
| S pneumoniae | 9 (6-16) | 224 | 134 | 11 (6-19) | 196 | 130 | 1.22 (0.99-1.49), .058 | 1.18 (0.94-1.48), .16 |
| H influenzae | 10 (6-18) | 243 | 154 | 11 (6-17) | 177 | 113 | 0.98 (0.79-1.22), .88 | 1.00 (0.78-1.27), .99 |
| M catarrhalis | 11 (6-18) | 215 | 128 | 10 (6-17) | 205 | 135 | 1.02 (0.82-1.27), .85 | 1.03 (0.84-1.27), .76 |
| Any bacteria | 9 (5-16) | 62 | 47 | 11 (6-17) | 358 | 180 | 1.22 (0.99-1.51), .059 | 1.17 (0.94-1.45), .15 |
GEE, Generalized estimating equations; IQR, interquartile range; IRR, incidence rate ratio.
∗
Sex; age at episode; father's asthma; mother's educational level; nicotine in the hair at age 1 year; sensitization at the ages of 6 months, 18 months, and 4 years asthma from 0-3 years of age; and chromosome 17q21 variant.