Table 2.
Clinical and microbial data of the CF patients.
| Virus-negative patients (n = 46) | Virus-positive patients (n = 4) | Associations/differences | |
|---|---|---|---|
| Age (range) | 25 ± 12 (1–68) | 19 ± 8 (11–29) | nsa |
| Gender (m:f) | 25:21 | 3:1 | nsa |
| Exacerbationsb/year (SD) | 4.45 (± 2.9) | 7.75 (± 2.1) | p = 0.03a |
| Colonization (%) with | |||
| S. aureus | 30 (65%) | 4 (100%) | RRc: 1.53 (CI95: 1.24–1.89) |
| MRSA | 5 (11%) | 2 (50%) | RRc: 4.60 (CI95: 1.28–16.59) |
| Ps. aeruginosa | 25 (54%) | 4 (100%) | RRc: 1.84 (CI95: 1.41–2.40) |
| Enterobacteriaceae | 15 (33%) | 0 (0%) | nsc |
| H. influenzae | 9 (20%) | 0 (0%) | nsc |
| Alcaligenaceae | 9 (20%) | 0 (0%) | nsc |
| S. maltophilia | 7 (15%) | 0 (0%) | nsc |
| Aspergillus fumigatus | 18 (39%) | 4 (100%) | RRc: 2.56 (CI95: 1.78–3.66) |
| Shwachman Score | 60 (± 13) | 61 (± 13) | nsa |
| BMId | 21 (5.6) | 21 (3.5) | nsa |
| Mutation: not dF508/dF508 | 19 (41%) | 3 (75%) | nsc |
| Mutation: not dF508/… or R553X/… | 1 (2%) | 1 (25%) | nsc |
| ABPAe | 5 (11%) | 1 (25%) | nsc |
| D. mellitus and/or D. insipidus | 13/5 (28/11%) | 0/0 (0/0%) | nsc |
| Pancreatic insufficiency | 42 (91%) | 4 (100%) | nsc |
a
Mann–Whitney U test.
b
Exacerbation (definition): consultation of the physician because of acute pulmonary deterioration suggestive for infection.
c
RR: risk ratio; CI95: 95% confidence interval.
d
BMI: body mass index.
e
ABPA: allergic bronchopulmonary aspergillosis.