Table 1.
Patient Characteristics
Patient | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | |
Age, years | 42 | 29 | 65 | 32 | 58 | 48 | 65 | 49 | 40 | 55 | 56 | 52 | 72 |
Sex | M | M | F | M | F | F | F | M | M | M | M | M | M |
Treatment type | MUD | MUD | Mini-MUD | MUD | Mini-MUD | MUD | Mini-MUD | MUD | MUD | MUD | MUD | Sibling allogeneic | Mini-MUD |
Diagnosis | PH + ALL | CML | CLL | NHL | AML | AML | MM | CML | AML | NHL | MDS | NHL | AML |
ECOG | 3 | 3 | 1 | 2 | 2 | 1 | 2 | 3 | 3 | 2 | 4 | 2 | 1 |
Graft-versus-host disease | Chronic skin, lung, liver | None | None | Chronic lung, sicca syndrome | None | None | None | Chronic lung | Chronic lung, eye, skin | Chronic liver | None | Acute skin | Pretransplantation |
Prednisone >20 mg | Yes | Yes | No | No | No | Yes | No | Yes | No | Yes | Yes | Yes | No |
Duration of symptoms before diagnosis | 5 days | Asymptomatic | 24 hours | 7 days | 5 days | 3 days | 4 days | > 1 month | 10 days | Unknown | 1 month | 24 hours | 2-3 days |
Time after treatment/engraftment status | 3 years/+ | 14 days/- | 6 days/- | 2 years/+ | 17 days/+ | 48 days/+ | 25 days/+ | 8 months/+ | 4.7 years/+ | 132 days/+ | 38 days/+ | 45 days/+ | Pretransplantation |
Pulmonary status | History of Pseudomonas pneumonia 3/04, 8/04, 3/05; 2 L O2 | O2 saturation 96% on RA; chest x-ray/computed tomography changes; crackles | O2 saturation 99% on RA | History of BOOP, O2 saturation 97% on RA | O2 saturation 90%-92% on RA | O2 saturation 99% on RA | O2 saturation 96% on RA | History of cytomegalovirus pneumonia 4/05; O2 saturation 97% on RA | Concomitant infection with C. galbrata, C. guilliermondii, MRSA (BAL) | On RA | Presented with rapid-onset respiratory failure before BAL,? DAH with CMV + effusions | O2 saturation 95% on RA | O2 saturation 100% on RA |
ALC | 200 | 0 | WBC 0.4 | 1000 | 200 | 400 | 500 | 1500 | WBC 5.3 No differential |
400 | WBC 3.5 No differential |
800 | 600 |
Ribavirin | i.v., HD, i.v. IG | No | Inhaled × 5 days, i.v. × 3 days | Inhaled × 7 days | Inhaled × 7 days | No | No | Inhaled × 7 days | Oral × 18 days, i.v. × 3 days | No | Inhaled ×x 3 days, i.v. × 7 days | No | No |
Symptoms | LRTI | LRTI | LRTI | LRTI | LRTI | URTI | LRTI | LRTI | LRTI | URTI | LRTI | URTI | URTI |
Outcome | Expired | Expired | Recovered | Expired | Recovered | Recovered | Recovered | Recovered | Recovered | Recovered | Expired | Recovered | Recovered |
BAL, Bronchoalveolar lavage, CML, chronic myelogenous leukemia; CLL, chronic lymphocytic leukemia; AML, acute myelogenous leukemia MUD, matched unrelated donor; MM, multiple myeloma MUD, matched unrelated donor; NHL, non-Hodgkin lymphoma.