Table 2.
RSV strains with nucleotide substitutions in the F gene region encoding the palivizumab binding site among 42 sequences evaluated.
| RSV subgroup | Nt substitutiona | Syn/NSynb | Predicted AA substitution | No. strains with mutation | RSV seasons (Oct–May) |
|---|---|---|---|---|---|
| A | G816A* | Syn | 1 | 2005 | |
| B | A780G* | Syn | 4 | 2(2001), 2003, 2004 | |
| B | T789C* | Syn | 1 | 2007 | |
| B | A813G* | Syn | 2 | 2006, 2007 | |
| A | A814G* | NSyn | K272E | 1 | 2005 |
| A | C827T# | NSyn | N276S | 1 | 2006 |
| B | A814C# | NSyn | K272Q | 1 | 2006 |
| B | C824T# | NSyn | S275L | 1 | 2001 |
a
(*)Single sequence identified; (#) mixed wildtype and mutant sequences.
b
Syn = synonomous base substitution; NSyn = nonsynonomous base substitution.