Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Mechanism of action of HERVs in MS.
| HERV | Disease pathogenesis | Mechanisms |
|---|---|---|
| HERV-W/Syncytin/MSRV | Up regulated in MS lesions | Induction of free radicals, ER stress and subsequent oligodendrocyte death; triggers toll-like receptor (TLR)-4 affecting innate and autoimmunity |
| HERV-H | Up regulated in lymphocytes of MS patients | Induction of antibodies against HERV; induces cell-mediated immune response to gag and env peptides; retrovirus-like particles (RVLPs) observed in cultured patient cells |
