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The pros and cons of 2′-O-methylated RNA as a genetic material.
| Better than RNA | Worse than DNA |
| The reactivity of the 2′-OH is eliminated. | Modification of the ribose is post-transcriptional. |
| 2′-OCH3 confers qualities similar to DNA as a genetic material. | 2′-O-methyl ribose would produce a hydrophobic cushion in the deep groove of the helix – full methylation may compromise genome functionality. |
