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Serum LAP levels in HIV-1 infected subjects
| Proviral load (copy/106 PBMC) | LAP activity (U/ml) | |
|---|---|---|
| Control (non-infected) | ||
| (>600 CD4 cell counts/μl) | — | 0.00047±0.00003 |
| Infected | ||
| (200–500 CD4 cell counts/μl) | 8–50 (n=8) | 1.43±0.23 |
| 50–170 (n=8) | 1.28±0.09 | |
One unit of LAPase is defined as the amount of enzyme required to hydrolyze 1 μmol of l-Leucine-β-naphthylamide to l-leucine and β-naphthylamide per min at pH 7.5 and 37°C.
