Supplementary Figure 2.

Dose-dependent inhibition of secreted HBV DNA by telbivudine (LdT) in 2215 cells. HepG2215 cells were treated at BL, and at 24, 48, and 72 hours with 0.04, 0.16, 0.65, 2.5, 10, and 20 μmol/L of LdT. The levels of secreted-virus (SV) HBV DNA were quantitated by real-time PCR. The mean values and the SD of 3 independent experiments are shown. *P values less than .05, **P values less than .01, and ***P values less than .001 for LdT-treated vs nontreated cells.