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. 2014 Oct 8;148(2):403–414.e7. doi: 10.1053/j.gastro.2014.10.004

Figure 7.

Figure 7

Telbivudine (LdT) plus alisporivir combination has a greater antiviral effect than alisporivir or telbivudine alone. HepG2215 cells were treated with 0.25, 1, 5, and 20 μg/mL of alisporivir alone and in combination with 10 μmol/L of LdT or 10 μmol/L of LdT alone. Cells and supernatants were collected every 24 hours. (A) Secreted-virus (SV) HBV DNA and (B) intracellular nucleocapsid-associated (INA) HBV DNA were quantified by real-time PCR. (C) sHBsAg and (D) iHBsAg were quantified by ELISA. Mean values and the SD of 3 independent experiments are shown. *P values less than .05, **P values less than .01, ***P values less than .001 for ALV/LdT-treated vs nontreated cells. †P values less than .05, ††P values less than .01 for alisporivir-treated vs ALV/LdT-treated cells.