Table 2.

Studies included in this review.

N	Author (year)	Design	Study population	Total study population	Geographical region	Main findings concerning human adenovirus B21	R
1	Scott M et al. (2016)	Prospective observational registry study	General population with human adenovirus infections	198 (20 adenovirus B21)	United States	•10% adenovirus B21 •patients were significantly older than others •pneumonia in 21% •hospitalization in 81% •30% admitted to the ICU •23% required mechanical ventilation	[9]
2	Hage E et al. (2014)	Observational study	Patients with human adenovirus B21 infections and pneumonia	6 (6 adenovirus B21)	Germany	•disease of children and middle aged adults •male predominance •>50% suffered from psychiatric comorbidity •all patients needed ICU admission for mechanical ventilation and •2 patients needed ECMO therapy	[11]
3	Gray et al. (2007)	Observational study	General population with human adenovirus infections	2237 (32 adenovirus B21)	United States	•OR = 7.6 for severe disease •longer ICU stay	[19]