Table I.
Summary of results from published whole-genome scans in asthma
| Chromosome | CSGA 129 | CSGA 230 | British/Australian28 | Hutterites31 | German Asthma Genetics Group32 |
|---|---|---|---|---|---|
| 2pter | BHR/asthma | IgE/RAST | |||
| 2q22-33 | Asthma, Hispanic | IgE (Der p 1) | |||
| 3p24.2-22 | BHR/asthma | ||||
| 4q35 | BHR | ||||
| 5p15 | Asthma, African American | ||||
| 5q23-33 | Asthma, white | IgE (Der p 1) | Asthma | ||
| 6p21.3-23 | Asthma, white | IgE (Der p 1) | IgE/Eos | Asthma, eosinophil, IgE/RAST | |
| 7p35 | IgE/BHR | ||||
| 8p23.3 | IgE (Der p 1) | ||||
| 9 (D9S925 and DS1784) | Asthma/BHR | Asthma, IgE/RAST | |||
| 11p15 | Asthma, white | ||||
| 11q13 | IgE/skin test | ||||
| 12q13 | Asthma | ||||
| 12q14-24.2 | Asthma, white | ||||
| Asthma, Hispanic | Asthma | ||||
| 13q14.3-32.2 | Asthma, white | IgE (Der p 1) | Atopy | BHR | |
| 14q11.2-13 | Asthma, white | ||||
| 16q24.1 | IgE/BHR | ||||
| 17p11.1-11.2 | Asthma, African American | ||||
| 19q13 | Asthma, white | Asthma | |||
| 21q21 | Asthma, Hispanic | Asthma/BHR | |||
| Linkage criteria | P < .01 | P < .001 | P < .001 | P < .01 | P < .01 |
Der p 1, Principal house dust mite allergen; RAST, radioallergosorbent test for allergen specific IgE.