Table II.
Candidate genes in asthma and allergy and their chromosomal locations
| Candidate | Chromosome location | Function |
|---|---|---|
| IL-3 | 5q31-33 | Eosinophil and basophil growth factor |
| IL-4 | 5q31-33 | IgE switching, TH2 polarization, up-regulation of VCAM-1, induction of mucus genes |
| IL-9 | 5q31-33 | Mast cell growth factor |
| β2-Adrenoceptor | 5q31-33 | Cyclic AMP–dependent signaling |
| LTC4 synthase | 5q35 | Cysteinyl Leukotriene generation |
| MHC class II | 6p21.3-23 | Antigen recognition |
| TNF-α | 6p21.3-2.3 | Pleiotropic cytokine |
| 5-Lipoxygenase | 10q11.2 | Leukotriene synthesis |
| FcϵRIβ chain | 11q13 | Regulation of IgE signaling |
| CC16 (CC10, uteroglobin) | 11q12-13 | Lung anti-inflammatory protein |
| NOS-1 | 12q24.3 | Neural nitric oxide production |
| TCR α chain | 14q11.2 | Antigen-driven immune responses |
| IL-4rα | 16p12 | IL-4 signaling |
| TGF-β1 | 19q13.1-13.3 | Increased IgE synthesis, profibrotic cytokine |
VCAM-1, Vascular cell adhesion molecule-1; LTC4, leukotriene C4; FcϵRI, high-affinity receptor of IgE; NOS-1, nitric oxide synthase-1; TCR, T-cell receptor.