Fig. 4.

Overview of the mutations found in the L and M genome segment of the seven Swiss SBV isolates before cell culture passaging (A) and after 10 passages in SK-6 cells (B), compared to the BH80/11-4 Genbank reference sequences for L (HE649912) and M (HE649913). Nucleotides identical to the reference sequence are labeled in light green, mutations in light red. Amino acid changes are labeled in yellow (conservative exchange) or red (non-conservative exchange). The German reference virus BH80/11-4 that had undergone repeated KC/BHK-21/SK-6 cell culture passaging (see Section 2) is marked by an asterisk. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)