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editorial
. 2011 Mar 17;30(4):361–374. doi: 10.1016/j.healun.2011.01.701

Table 3b.

Cytomegalovirus (CMV) in CTTX

CMV infection Without clinical symptoms CMV detection in blood by viral culture, antigenemia or molecular diagnostics (DNA-based assay)
CMV pneumonitis (proven)

  • Including but not limited to:

  •  • Fever >38oC not attributable to extrapulmonary source

  •  • Hypothermia( <36.5°C)

  •  • Leucopenia (<4,000 WBC/mm3)

  •  • Cough

  •  • Dyspnea

  •  • Hypoxia (new-onset or increasing)

  •  • New or increased O2 requirement

  • New crackles, rales or wheezing

 New/worsening radiographic changes on chest X-ray or CT scan Detection of CMV in lung tissue by culture, immunohistochemistry or in situ molecular diagnostics, with OR without CMV detection in blood or BAL by viral culture, antigenemia or molecular diagnostics (DNA-based assay)
CMV pneumonitis (probable)8 As in proven CMV pneumonitis New/worsening radiographic changes on chest X-ray or CT scan CMV detection in blood or BAL by viral culture, antigenemia or molecular diagnostics (DNA-based assay)
CMV replication without clinical pneumonitis Without clinical symptoms No changes to chest X-ray or CT CMV detection in BAL by viral culture, antigenemia or molecular diagnostics (DNA-based assay)