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. 2017 Jun 28;207:248–258. doi: 10.1016/j.vetmic.2017.06.019

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© 2017 Elsevier B.V. All rights reserved.

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Fig. 5 — Histopathology of the intestines of piglets inoculated with the parental and cell-adapted DEL strains. (A–F) Hematoxylin and eosin-stained tissue sections of the jejunums from virus-inoculated and negative-control pigs (100× magnification). Jejunums from piglets infected with the virulent KNU-141112-P5 strain showed acute diffuse, severe atrophic enteritis with vacuolation of superficial epithelial cells (panel E). The normal villous epithelium of the jejunums was recorded in pigs inoculated with KNU-141112-S DEL2/ORF3 (panels A and B) and –S DEL5/ORF3 (panels C and D), and a mock-inoculated piglet (panel F). (G–L) Detection of PEDV antigen by IHC analysis of jejunum tissue sections from virus-inoculated and negative-control pigs (200× magnification). PEDV antigen signals appear brown and were detected in epithelial cells in the jejunums of all PEDV KNU-141112-P5-inoculated piglets (panel K). No PEDV antigen was detected in the jejunums of piglets inoculated with KNU-141112-S DEL2/ORF3 (panels G and H) or –S DEL5/ORF3 (panels I and J), or a mock-inoculated piglet (panel L).