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. Author manuscript; available in PMC: 2020 Apr 21.
Published in final edited form as: Adv Ther (Weinh). 2019 Sep 13;2(11):1900111. doi: 10.1002/adtp.201900111

Table 1.

Pharmacokinetic parameters of bioengineered exosomes.

Pharmacokinetics TG42-Exo TG44-Exo WuA108-Exo WuA110-Exo
Half-life t1/2α [min] 6.85 7.84 26.18 8.79
Half-life t1/2β [min]) 149 185 792 390
kel [min−1] 0.0052 0.0041 0.0003 0.0009
AUC [%ID·g−1 min−1] 11537 9871 25759 5922
Plasma clearance [mL·min−1] 0.0118 0.0154 0.0054 0.0126
Volume of distribution [mL] 2.4321 3.0356 5.3709 8.4773