Table 1.
Baseline characteristics of selected human bocavirus and respiratory syncytial virus RT-PCR-positive patients admitted to the paediatric intensive care unit at the Erasmus MC-Sophia from 2007 to 2012
| Characteristics | HBoV-positive PICU cases (n = 7) | RSV-positive PICU cases (n = 17) |
|---|---|---|
| Age, median (min–max, IQR) | ||
| Months | 24 (4–31, 14.3–31.3) | 2 (0–39, 0–7.5) |
| Years | 2 (0.3–2.62, 1.19–2.60) | 0.18 (0.02–3.26, 0.06–0.68) |
| Female, n (%) | 4 (57) | 5 (29) |
| Male, n (%) | 3 (43) | 12 (71) |
| Reason for admission, n (%) | ||
| Respiratory failure | 3 (43) | 16 (94) |
| ECMO indication due to respiratory failure | 1 (14) | — |
| Bronchiolitis/PSA | 3 (43) | — |
| ALTE with ARTI | — | 1 (6) |
| Clinical diagnosis at admittance, n (%) | ||
| URTI | — | 1 (6) |
| LRTI | 1 (14) | 1 (6) |
| BHR/PSA | 4 (57) | — |
| ARDS | 1 (14) | — |
| Severe atelectasis with ARTI | 1 (14) | — |
| Bronchiolitis | — | 15 (88) |
| Medical history, n (%) | ||
| None | 3 (43) | 6 (35) |
| Pulmonary disease | 3 (43) | 2 (12) |
| GSA <37 weeks | — | 2 (12) |
| GSA <37 weeks and pulmonary disease | 1 (14) | — |
| Cardiac disease | — | 1 (6) |
| Congenital anatomical malformations | — | 4 (24) |
| Macrosome or dysmature | — | 2 (12) |
| Laboratory testing, median (min–max, IQR) | ||
| CRP (mg/L) | 8 (1–36, 5–28) | 8 (2–22, 4–11.5) |
| WBC count (×109/L) | 13.6 (8.1–27, 9.3–20) | 13.5 (8.7–33, 10.5–15) |
| Sputum obtained and start antibiotics, n (%) | ||
| ≤ 12 hours before sputum obtained | 1 (14) | 3 (17) |
| > 12 hours after sputum obtained | 4 (57) | 4 (24) |
| Sputum not obtained, n (%) | 2 (28) | 10 (59) |
| Respiratory support, n (%) | ||
| Supplemental | 1 (14) | 7 (41) |
| Invasive | 5 (72) | 10 (59) |
| ECMO | 1 (14) | — |
| PICU admission duration (days) median (min–max) | 4 (2–7) | 4 (2–29) |
| Survival, n (%) | 7 (100) | 17 (100) |
| Viral metagenomics, n (%) | ||
| HBoV as sole viral pathogen detected | 7 (100) | — |
| RSV as sole viral pathogen detected | — | 14(82)a |
Abbreviations: ALTE, acute life-threatening event; ARDS, acute respiratory distress syndrome; ARTI, acute respiratory tract infection; BHR, bronchial hyperreactivity; CRP, C-reactive protein; ECMO, extracorporeal membrane oxygenation; GSA, gestational age; HBoV, human bocavirus; LRTI, lower respiratory tract infection; PICU, paediatric intensive care unit; PSA, paediatric status asthmaticus; RSV, respiratory syncytial virus; URTI, upper respiratory tract infection; WBC, white blood cells.
One sample could not be processed, one tested negative for viruses, one tested positive for rhinovirus.