Table 1.

A summary of the efficacy of some anti-viral therapies used in controlling clinical colds

Therapy	Observed reduction in the following symptomsa						Limitationb	Reference
	Frequency of colds	Duration of colds	Total symptom score	Viral titre	Nasal secretion weight	Markers of inflammation
Anti-viral compounds
Ruprintrivir	⨯	NS	√	√	√	NS		[114]
Pirodavir	NS	⨯	⨯	√	NS	NS	Side effects/poor efficacy	[113]
WIN54954	⨯	NS	⨯	⨯	⨯	NS	Poor efficacy	[111
R61837	√	NS	√	NS	√	NS		[112]
Pleconaril	NS	√	√	NS	NS	NS	Side effects	[116]
Soluble ICAM derivatives
Tremacamra	√	NS	√	√	√	√		[121]
Type I IFN therapy
IFN-α2	√/⨯	⨯	√	√	√	NS	Side effects	[128], [129], [130], [131], [132], [133]
IFN-β	⨯	⨯	√/⨯	√/⨯	√/⨯	NS	Side effects/poor efficacy	[134], [135], [136]

^aRefers to the symptoms studied by the authors. √ refers to successful control of the symptom being studied. ⨯ refers to unsuccessful control of that particular symptom. NS refers to the symptom not being studied.

^bLimitations are those as suggested by the authors in each study.