Fig. 1.
HRV-14 3Cpro structure, mutation data and basic residues. (A) Cartoon rendering. Two six-stranded β-barrels (peach and lavender ribbons) are joined by a long linker (yellow; residues 76–97). Basic and non-basic residues that, when mutated, inhibit RNA-binding (Andino et al., 1993; Leong et al., 1993) are shown as teal and green sticks, respectively. Side chains of other nearby basic residues are shown as dark blue sticks. The active site catalytic triad (grey spheres) is in the rear of the molecule in this view and contains the inhibitor JMC-98-3 (inhibitor not shown). (B) Surface rendering. Orientation and coloring are as in part A. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)