Fig. 8.
Allosteric effects at the 3Cpro proteolytic active site. Chemical shift perturbations upon addition of SLD, plotted onto a cartoon view of 3Cpro, with the catalytic triad side chains shown as yellow sticks with yellow labels. Color scheme is otherwise identical to Fig. 5A. The viewing angle is roughly intermediate between the two views of Fig. 5A. The terminal residues of four β-strands (strand 2, F25–I30; strand 3, V34–I37; strand 10, 147–150; strand 11, 157–163) are labelled for reference in the text. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)