Table 2.
ORF1 polymorphic positions in reference sequences (PP%) and mutations in IC sequence.
| Protein | Methyltransferase (AA 56–240) | Y domain (AA 216–433) | Polyproline region (variable) | Protease (AA 433–592) | X domain (AA 795–968) | Helicase (AA 970-1202) | RNA polymerase (AA 1217–1703) |
|---|---|---|---|---|---|---|---|
| Summarized function | mRNA ribosome binding, innate immunity (Holla et al., 2013) | Unknown | Adaptation (Holla et al., 2013) and immune response modulation (Karpe and Meng, 2012) | Protease (Suppiah et al., 2011), deubiquitination and cellular immunity (Karpe and Meng, 2012) | Unknown | Helicase (Holla et al., 2013) | Replication (Ahmad et al., 2011) |
| Length (AA) | 184 | 218 | Variable (1) | 160 | 174 | 233 | 487 |
| (PP%) | 5 | 0.40 | 19 | 22 | 6 | 7 | |
| IC sequence mutations | No mutations | No mutations | No insertions. No deletions. | H495C | T938 M, T856 V, S898A | S1014N, S975T, Q1133 K | D1235G, Q1242R, S1454T, V1480I, I1502 V, K1511R, G1373 V, E1442D, V1693 M |
(1) 110 AA in most of the sequences (n = 43); 114 AA (n = 2); 131 AA (n = 3); 172 AA (n = 3);107 AA (n = 7); 108 AA (n = 3); 109 AA (n = 1).