Table 3.
ORF2 and ORF3 polymorphic positions in reference sequences (PP%) and mutations in IC sequence.
| ORF2 protein |
ORF3 protein |
|||||||
|---|---|---|---|---|---|---|---|---|
| S domain (N-terminal) (AA 1–113) |
S domain (C-terminal) (AA 114–317) |
M domain (AA 318–451) |
P domain (AA 452–660) |
D1 domain | D2 domain | P1 domain | P2 domain | |
| Summarized function | Capsid (Xing et al., 2010) | Connecting S and P domains (Xing et al., 2010) | Neutralizing antibodies binding and cellular receptor (Holla et al., 2013) | Cell survival signal (Zafrullah et al., 1997) | Innate immune response Ratra, (Kar-Roy et al., 2008) | ORF2 interaction (ser71) (Ahmad et al., 2011) | Virus release (Ahmad et al., 2011) | |
| Length (AA) | 113 | 203 | 133 | 208 | 122 | |||
| (PP%) | 22 | 1 | 0.70 | 6 | 0 | 16 | 35 | 25 |
| IC sequence mutations | F10L, S26T, G36S, S70P, A105V, I113V | No mutations | T426A | No mutations | No mutations | A36V | No mutations | P110S (included in PXXP motif) |