Table 1.
Angiogenic cell surface receptors/homing motifs isolated by in vivo phage display
| Receptor | Function/class | Carrier? | Localization | Homing motif |
|---|---|---|---|---|
| GRP 78 | Stress response | Yes | Tumor cells | WIFPWIQL |
| αv Integrins | Cell adhesion | Yes | EC, tumor cells | RGD4C |
| CD13 | Protease | Yes | EC, pericytes | CNGRC |
| APA | Protease | N/D | Pericytes, stromal cell | CPRECES |
| NG2/HMWMAA | Proteoglycan | N/D | Pericytes, tumor cells | GSL |
| MMP-2/MMP-9 | Protease | Yes | EC, tumor cells | CTTHWGFTLC |
| IL-11-R | Cytokine receptor | Yes | EC, tumor cells | CGRRAGGSC |
| Prohibitin | Membrane chaperone | Yes | EC | CKGGRAKDC |
| HSP90 | Heat shock | Yes | EC, tumor cells | CVPELGHEC |
EC, endothelial cells; N/D, not determined.