Figure 3.

HCV-Mediated Subversion of Lipid Homeostasis Implicated in MW Biogenesis

HCV induces extensive remodeling of intracellular membranes, most notably double-membrane vesicles (DMVs) and less frequently multimembrane vesicles (MMVs). Right panel: model of HCV-subverted host cell proteins and lipids implicated in MW biogenesis. PI4KIIIα interacts with NS5A and NS5B to induce elevated levels of PI4P (1). Subsequently, oxysterol-binding protein (OSBP) delivers cholesterol to HCV-remodeled membranes. OSBP recruitment is facilitated by locally elevated PI4P levels as well as interactions with VAPs and NS5A (2). For comparison, a naive cell is shown in the left panel.