. 2008 Oct 6;121(1):1–13. doi: 10.1016/j.pharmthera.2008.09.003

Table 2.

Available small molecule IKK-β inhibitors

Compound	IC50, assay	Reference
TPCA-1	0.17–0.32 μM, pro-inflammatory cytokine expression in monocytes	(Podolin et al., 2005)
2-[(Aminocarbonyl)amino]-5-[4-fluorophenyl]-3-thiophenecarboxamide		(Podolin et al., 2005)
PS-1145	Data not provided	(Hideshima et al., 2002)
N-(6-chloro-9H-beta-carbolin-8-ly) nicotinamide	Data not provided	(Hideshima et al., 2002)
ML120B	3.3 μM TNF-α expression in PBMCs	(Wen et al., 2006)
N-(6-chloro-7-methoxy-9H-beta-carbolin-8-yl)-2-methyl-nicotinamide	3.3 μM TNF-α expression in PBMCs	(Wen et al., 2006)
SC-514	8–20 μM pro-inflammatory cytokine expression in synovial fibroblasts	(Kishore et al., 2003)
5-(Thien-3-yl)-3-aminothiophene-2-carboxamide		(Kishore et al., 2003)
IMD-0354	Data not provided	(Onai et al., 2004)
N-[3,5-bis-trifluoromethyl-phenyl]-5-chloro-2-hydroxy-benzamide	Data not provided	(Onai et al., 2004)
BMS-345541	4 μM IκB phosphorylation in THP-1 cells	(Burke et al., 2003)
4(2′-aminoethyl)amino-1,8-dimethylimidazo(1,2-aquinoxaline)	4 μM IκB phosphorylation in THP-1 cells	(Burke et al., 2003)
BAY 11-7085	10 μM, adhesion molecule expression in HuVEC cells	(Pierce et al., 1997)
3-[4-t-butylphenyl)-sulfonyl]-2-propenenitrile	10 μM, adhesion molecule expression in HuVEC cells	(Pierce et al., 1997)
AS602868	1–2 μM, NF-κB activation in Jurkat T cells	(Frelin et al., 2003)