Fig. 4.

A) Crystal structure of rat STING in complex with 2′3′-cGAMP (PDB code: 5GRM); B) Crystal structure of hSTING(G230I) in complex with DMXAA (PDB code: 4QXP). The DMXAA, S162, G230 and Q266 are colored green, cyan, red and yellow respectively; C) Crystal structure of human STING in complex with diABZI1 (PDB code: 6DXL); D) Crystal structure of human STING (G230A, H232R, R293Q) in complex with C18 (PDB code: 6MXE). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)