Table 15.
Efficacy of 12.5 mg ombitasvir + 75 mg paritaprevir + 50 mg ritonavir fixed-dose two pills QD plus 250 mg dasabuvir BID plus ribavirin for 24w.
Cirrhosis | Prior treatment | SVR12 rate in GT-1 | Study and trial phase | Ref. |
---|---|---|---|---|
Cirrhosis | Naïve | 1a: 92.9% (52/56), 1b:100% (18/18) | TURQUOISE-II, phase 3 | Poordad et al., 2014 |
Null response to PegIFNα/RBV | 1a:92.9% (39/42), 1b:100% (20/20) | |||
Partial response to PegIFNα/RBV | 1a: 100% (10/10), 1b:100% (3/3) | |||
Relapse to PegIFNα/RBV | 1a: 100% (13/13), 1b:100% (10/10) |