Table 2.

Summary of genes significantly modified at 8 and 24 h after oral IFN at 0, 50, 200 or 800 units per dose. (Negative values = down-regulation, positive values = up-regulation).

		t = 8 h		t = 24 h
Genes	Conc., Units	Fold Regulation	p-value	Fold Regulation	p-value
IFNAR2	0			1.36	0.046
IRAK2	0	−1.60	0.020	−1.36	0.007
MAP3K13	0	−1.79	0.020
MAPK14	0	−1.72	0.010	−1.36	0.049
TGFB3	0	−2.68	0.030
TLR6	0	−2.72	0.010
ANXA1	50	−3.59	0.005
ANXA5	50	−2.79	0.0004	−1.57	0.027
CCL19	50	−5.87	0.009
CCRL1	50	−3.43	0.008
CSF1	50	−1.53	0.002
CXCL12	50	−4.41	0.019
FAS	50	−2.10	0.002	−1.72	0.003
IL16	50	−1.59	0.035
IL2RA	50	−2.18	0.012
IL6R	50	−1.71	0.008
IRAK2	50	−1.47	0.049
ITGAL	50	−2.56	0.012	−2.50	0.030
ITGB2	50	−1.68	0.027
PTGDR	50	−2.56	0.015
RAB5C	50	−1.44	0.002	−1.24	0.029
SELP	50	2.99	0.010
TGFB3	50	−3.77	0.021
TGFBR1	50	−2.30	0.006	−1.81	0.044
TLR4	50	−2.29	0.018
TNFRSF1A	50	−2.62	0.009
TNFSF13B	50	−5.58	0.0004	−1.69	0.027
WWP1	50	−1.99	0.018
CCL19	200	2.83	0.002
CCL8	200	1.47	0.020
CCRL1	200			−1.67	0.026
CREBBP	200			−1.47	0.007
CXCL6	200	1.60	0.040
CXCR2	200			6.09	0.043
EDN1	200	4.33	0.000	3.36	0.050
GRO1	200	2.67	0.046
ICAM1	200	2.25	0.004
IFNAR2	200	1.90	0.028
IKBKB	200			−1.77	0.012
IL10	200	2.41	0.025
IL10RB	200	1.43	0.022
IL1A	200	19.90	0.000
IL1B	200	4.88	0.004
IL6	200	1.75	0.008
IL6R	200	−1.62	0.014	−1.51	0.015
IRF9	200	−4.42	0.006	−3.52	0.003
ITGB2	200			−1.25	0.007
NFKBIA	200	2.68	0.004
PTGS2	200	2.25	0.019
SMAD4	200			−1.53	0.037
TNF	200	−2.14	0.027
IFNG	800	−2.54	0.034
IL10	800	2.03	0.045
MAPK14	800	−1.30	0.037
TGFB1	800	−1.64	0.046	−1.43	0.002
VEGFA	800	1.51	0.010