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Fusion of two lipid bilayers. (A) Two parallel bilayer membranes. There is a substantial barrier to close approach. (B) Hemifusion stalk. (C) Proposed transition structure. (D) Fusion pore (before lateral expansion). (E) Hemifusion diaphragm. (F) Some models include perforation of the hemifusion diaphragm as a productive step toward fusion pore formation. Adapted from Jahn et al. (2003); see also Cohen et al. (2002).
