Table II.
Counts of phenotype of inflammatory cells infiltrating in epithelial and subepithelial areas in bronchial mucosa of subjects with COPD and control subjects
| Groups | COPD |
Healthy smokers |
Healthy nonsmokers |
|||||
|---|---|---|---|---|---|---|---|---|
| Baseline (N = 17) | Day 7 (N = 17) | Week 6 (N = 11) | Baseline (N = 20) | Day 7 (N = 20) | Week 6 (N = 12) | Baseline (N = 11) | Day 7 (N = 11) | |
| Epi∗ | ||||||||
| Neutrophil elastase+ | 4 (1-18) | 8† (1-46) | 14† (2-47) | 3 (0-30) | 8 (0-36) | 10 (0-47) | 4 (16-0.4) | 4 (0-24) |
| EG2+ | 0 (0-6) | 0.4 (0-11) | 0.4 (0-12) | 0.2 (0-8) | 0.4 (0-31) | 0.3 (0-5) | 0 (0-19) | 0.7 (0-68) |
| Tryptase+ | 3 (0-16) | 3 (0-8) | 4 (0-14) | 3 (0-35) | 3 (0-21) | 11 (0-25) | 2 (0-9) | 3 (0-16) |
| CD68+ | 11 (1-61) | 18 (1-86) | 31 (4-56) | 15 (1-51) | 24†‡ (5-88) | 13 (0-77) | 8 (3-27) | 14 (4-22) |
| CD4+ | 3 (0-14) | 8† (0-96) | 5 (2-70) | 3 (0-13) | 6†§ (1-39) | 2 (0-18) | 4 (0-11) | 8† (2-44) |
| CD8+ | 55‖ (31-183) | 67‡ (27-178) | 94 (39-253) | 67‖ (7-187) | 72‡ (30-165) | 73 (20-116) | 38 (9-72) | 321 (15-96) |
| CD20+ | 0 (0-0.3) | 1† (0-19) | 0 (0-2) | 0 (0-3) | 2† (0-5) | 0 (0-4) | 0 (0-2) | 0.5† (0-6) |
| Sub∗ | ||||||||
| Neutrophil elastase+ | 109 (40-337) | 135 (64-445) | 155 (72-201) | 135 (22-492) | 148 (27-564) | 117 (18-289) | 125 (44-295) | 149 (67-469) |
| EG2+ | 11 (0-87) | 72† (11-349) | 23 (2-169) | 11 (0-66) | 25 (1-257) | 34 (0-199) | 12 (0-66) | 38 (1-176) |
| Tryptase+ | 301 (119-480) | 220† (72-347) | 184† (140-323) | 341 (73-661) | 220† (77-576) | 300 (15-605) | 310 (109-531) | 248 (61-459) |
| CD68+ | 201‖ (95-388) | 334† (61-603) | 228 (138-379) | 234‖ (55-633) | 302† (97-883) | 217 (125-506) | 127 (102-182) | 294† (161-559) |
| CD4+ | 66‖ (37-296) | 221† (12-666) | 167 (75-406) | 142‖ (14-251) | 226† (36-1014) | 83 (29-447) | 199 (67-293) | 230 (32-342) |
| CD8+ | 243‖ (142-816) | 429†‡ (148-1003) | 408† (311-593) | 376‖ (90-910) | 491‡ (117-1420) | 541 (31-736) | 159 (63-278) | 236† (163-533) |
| CD20+ | 9‖ (2-44) | 23† (4-270) | 13 (6-138) | 9‖ (0-39) | 29† (0-406) | 16 (0-51) | 18 (5-46) | 20 (9-215) |
∗
Values are medians (ranges) of positive cell counts per 0.1 mm2 epi and per mm2 sub.
†
P = .0005-.044 vs their own baselines, respectively.
‡
P = .011-.049 vs nonsmoker day 7, respectively.
§
P = .031 vs its own week 6.
‖
P = .0005-0.047 vs nonsmoker baseline.