Figure 2.

Molecular Interface between Autophagy and Membrane Biology

Multiple components of the molecular machinery for autophagy mediate non-autophagic functions linked to the rearrangement and trafficking of intracellular membranes independently of bona fide autophagic responses. In this setting, different supramolecular entities can be assembled around components of the class III phosphatidylinositol 3-kinase complex that drives autophagy (A) to differentially regulate specific non-autophagic functions, including LC3-associated phagocytosis (C), endocytosis (C), melanogenesis (D), cytokinesis (E), and GA-to-ER transport (F).

ER, endoplasmic reticulum; GA, Golgi apparatus; PI3P, phosphatidylinositol 3-phosphate.