Table 2.

Nucleos(t)ide-based multi-target drugs in the treatment of HBV and HIV infections.

Nucleos(t)ide-type drugs with multi-target activity	Approved anti-HBV monotherapy	Approved combination drug for HIV
Tenofovir disoproxil fumarate (TDF)	Viread, Gilead, 2008	Viread, Gilead Sciences, 2001 (tenofovir disoproxil fumarate) Truvada, Gilead Sciences, 2004 (emtricitabine + tenofovir disoproxil fumarate) Atripla, Gilead Sciences, Bristol-Myers Squibb, 2006 (emtricitabine + efavirenz + tenofovir disoproxil fumarate) Complera, Gilead Sciences, 2011 (emtricitabine + rilpivirine + tenofovir disoproxil fumarate) Stribild, Gilead Sciences, 2012 (elvitegravir + cobicistat + emtricitabine + tenofovir disoproxil fumarate) Delstrigo, Merck, 2018 (doravirine + lamivudine +tenofovir disoproxil fumarate) Cimduo, Mylan Pharmaceuticals, 2018 (lamivudine + tenofovir disoproxil fumarate) Symfi Lo, Mylan Pharmaceuticals, 2018 (efavirenz + lamivudine + tenofovir disoproxil fumarate)
Tenofovir alafenamide fumarate (TAF)	Vemlidy, Gilead, 2016	Genvoya, Gilead Sciences 2015 (elvitegravir + cobicistat + emtricitabine, + tenofovir alafenamide) Descovy, Gilead Sciences, 2016 (emtricitabine + tenofovir alafenamide) Odefsey, Gilead Sciences, 2016 (emtricitabine + rilpivirine + tenofovir alafenamide) Symtuza, Janssen Therapeutics, 2018 (darunavir + cobicistat + emtricitabine + tenofovir alafenamide) Biktarvy, Gilead Sciences, 2018 (bictegravir + emtricitabine + tenofovir alafenamide)
Lamivudine (3TC)	Epivir, Glaxo Wellcome, 1998	Combivir, ViiV Healthcare, 2000 (lamivudine + zidovudine) Trizivir, ViiV Healthcare, 2000 (abacavir + lamivudine + zidovudine) Epzicom, ViiV Healthcare, 2004 (abacavir + lamivudine) Triumeq, ViiV HealthCare, 2014 (abacavir + dolutegravir + lamivudine) Dutrebis, Merck, 2015 (lamivudine + raltegravir) Delstrigo, Merck, 2018 (doravirine + lamivudine +tenofovir disoproxil fumarate) Cimduo, Mylan Pharmaceuticals, 2018 (lamivudine + tenofovir disoproxil fumarate) Symfi Lo, Mylan Pharmaceuticals, 2018 (efavirenz + lamivudine + tenofovir disoproxil fumarate) Dovato, ViiV Healthcare, 2019 (dolutegravir + lamivudine)