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. 2010 Mar 31;76:123–177. doi: 10.1016/S0065-3527(10)76004-8

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Copyright © 2010 Elsevier Inc. All rights reserved.

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A summary model on the defined and proposed functions of all the characterized host factors during TBSV replication. TBSV replication is divided into six sequential steps and preceded by translation of the TBSV replication proteins. Host factors shown in green circles and green arrows are required, while factors shown in blue circles and blue arrows are inhibitory for TBSV replication. Note that the ESCRT protein circle represents seven of the identified ESCRT proteins. Hsp70 is colored uniquely due to the essential role of Hsp70 in several steps in TBSV replication. The active p33 proteins are represented by black circles, while the inactive (phosphorylated form) is shown with pink circles. Also, the inactive p92 protein is shown as a red circle, while the activated p92 is represented by a green circle.