Table 3.
Comparison of the levels of the 13 metabolites between fatal (n = 16) and non-fatal (n = 126) CAP cases, and between patients in the high risk class (n = 34) and those in low risk class (n = 108).
| Metabolites | Fold differences between fatal and non-fatal CAP casesa | P value | Fold differences between high risk and low risk CAP casesa, b | P value |
|---|---|---|---|---|
| L-palmitoylcarnitine | +1.17 | 0.524 | +1.38 | 0.0736 |
| Tetrahexosylceramide (d18:1/16:0) | +1.22 | 0.136 | +1.14 | 0.211 |
| Trihexosylceramide (d18:1/16:0) | +1.35 | 0.0188 | +1.09 | 0.425 |
| Lactosylceramide (d18:1/16:0) | +1.26 | 0.114 | −1.01 | 0.942 |
| LysoPC(18:1[9Z]) | −1.30 | 0.246 | −1.47 | 0.0234 |
| LysoPE(16:0/0:0) | −1.29 | 0.0634 | −1.12 | 0.225 |
| LysoPE(18:0/0:0) | −1.20 | 0.177 | −1.13 | 0.198 |
| LysoPE(18:1[9Z]/0:0) | −1.52 | 0.0396 | +1.19 | 0.16 |
| LysoPE(18:2[9Z,12Z]/0:0) | −1.68 | 0.0190 | −1.43 | 0.0154 |
| LysoPE(20:4[8Z,11Z,14Z,17Z]/0:0) | −1.42 | 0.0370 | −1.47 | 0.00116 |
| LysoPE(22:6[4Z,7Z,10Z,13Z,16Z,19Z]/0:0) | −1.47 | 0.0357 | −1.63 | 0.000253 |
| SM(d18:0/16:0) | +1.32 | 0.195 | +1.06 | 0.743 |
| SM(d18:1/16:0) | +1.05 | 0.443 | −1.02 | 0.668 |
a
“+” indicates the level is higher in fatal cases than that of non-fatal cases. “−” indicates that the level is lower in fatal cases than that of non-fatal cases
b
High risk = Pneumonia Severity Index class V; Low risk = Pneumonia Severity Index class 4 or below.