Table 1.
Analytic performance of rRT-PCR, Luminex xTAG RVP, and BinaxNOW Influenza A & B RIDTa
| Influenza A 2009 H1N1 test method | Sensitivity | Specificity | PPVc | NPV | Prevalence | TP | TN | FP | FN |
|---|---|---|---|---|---|---|---|---|---|
| BinaxNOW Influenza A & B RIDT | 42.3 (31.4–54.0)b | 98.0 (95.7–99.1) | 82.5 (66.6–92.1) | 88.3 (84.6–91.3) | 18.3 (14.8–22.4) | 33 | 341 | 7 | 45 |
| LDT SOIA rRT-PCR | 98.9 (92.9–99.9) | 98.9 (97.0–99.7) | 95.6 (88.4–98.6) | 99.7 (98.2–100) | 19.4 (15.9–23.4) | 86 | 358 | 4 | 1 |
| CDC 2009 H1N1 LC480 rRT-PCR | 78.2 (67.8–86.0) | 99.7 (98.2–100) | 98.6 (91.1–99.9) | 95.0 (92.2–96.9) | 19.4 (15.9–23.5) | 68 | 360 | 1 | 19 |
| Luminex xTAG RVP | 93.1 (85.0–97.2) | 99.5 (97.8–99.9) | 97.6 (90.8–99.6) | 98.4 (96.3–99.3) | 19.4 (15.9–23.5) | 81 | 359 | 2 | 6 |
a
Positivity is defined as requiring 2 or more positive results obtained by rRT-PCR or xTAG RVP.
b
95% Confidence intervals.
c
PPV = positive predictive value; NPV = negative predictive value; TP = true positive; TN = true negative; FP = false positive; FN = false negative.