Table 4.
Correlation between Different Clinicopathological Characteristics and both c-Myc Nuclear and Cytoplasmic Expression of the Overall Tumor
| Clinicopathological characteristics | H-score of nuclear expression of the overall tumor |
H-score of cytoplasmic expression of the overall tumor |
||
|---|---|---|---|---|
| Median/ r value | p value * | Median/ r value | p value * | |
| Variant of UC | < 0.001 | 0.014 | ||
| Conventional (N = 62) | 100.00 | 270.00 | ||
| Sarcomatoid (N = 4) | 300.00 | 300.00 | ||
| Differentiation of UC** | 0.428 | 0.721 | ||
| Squamous (N = 29) | 110.00 | 280.00 | ||
| Absent (N = 35) | 100.00 | 270.00 | ||
| Bilharziasis | 0.733 | 0.524 | ||
| Present (N = 39) | 130.00 | 280.00 | ||
| Absent (N = 27) | 110.00 | 260.00 | ||
| Necrosis | 0.318 | 0.705 | ||
| Present (N = 33) | 90.00 | 270.00 | ||
| Absent (N = 33) | 120.00 | 270.00 | ||
| PNI | 0.037 | 0.990 | ||
| Present (N = 61) | 110.00 | 270.00 | ||
| Absent (N = 5) | 60.00 | 280.00 | ||
| LVI | < 0.001 | 0.747 | ||
| Present (N = 45) | 130.00 | 270.00 | ||
| Absent (N = 21) | 60.00 | 280.00 | ||
| pT stage | 0.084 | 0.350 | ||
| T2a (N = 3) | 160.00 | 270.00 | ||
| T2b (N = 11) | 60.00 | 280.00 | ||
| T3a (N = 5) | 60.00 | 280.00 | ||
| T3b (N = 36) | 105.00 | 260.00 | ||
| T4a (N = 11) | 210.00 | 280.00 | ||
| pN stage | < 0.001 | 0.445 | ||
| N0 (N = 41) | 70.00 | 270.00 | ||
| N1 (N = 6) | 185.00 | 275.00 | ||
| N2 (N = 19) | 180.00 | 270.00 | ||
| M stage | 0.042 | 0.229 | ||
| M0 (N = 62) | 100.00 | 270.00 | ||
| M1b (N = 4) | 195.00 | 275.00 | ||
| Stage grouping | 0.001 | 0.509 | ||
| II (N = 10) | 60.00 | 250.00 | ||
| IIIA (N = 35) | 80.00 | 270.00 | ||
| IIIB (N = 17) | 160.00 | 270.00 | ||
| IVB (N = 4) | 195.00 | 275.00 | ||
| Recurrence | 0.173 | 0.684 | ||
| Present (N = 8) | 95.00 | 260.00 | ||
| Absent (N = 40) | 160.00 | 270.00 | ||
| Age (y) | -0.071 | 0.573 | -0.059 | 0.638 |
| Tumor diameter (cm) | 0.142 | 0.257 | 0.084 | 0.500 |
LVI, lymphovascular invasion; N, total number of cases; PNI, perineural invasion; UC, urothelial carcinoma; * p value by Mann-Whitney U-test and Kruskal Wallis test for comparing two or more independent groups and by Spearman’s rho correlation for correlation between two ranked variables; ** Glandular group was excluded from analysis as they were only 2 cases.