Table 2.
Testosterone and Cardiovascular Events in Older Men Cardiovascular Outcomes by Quartile of Serum Total Testosterone Among Men With No Prior Cardiovascular Disease Events
| Clinical outcomes during follow-up, n (%) | Overall | T quartile 1 < 307 ng/dL | T quartile 2 307-391 ng/dL | T quartile 3 391-495 ng/dL | T quartile 4 ≥ 495 ng/dL | P-valuea |
|---|---|---|---|---|---|---|
| (N = 552) | (N = 139) | (N = 135) | (N = 136) | (N = 142) | ||
| Cardiovascular outcomes | ||||||
| Incident CHD event | 90 (16.3) | 28 (20.1) | 17 (12.6) | 20 (14.7) | 25 (17.6) | 0.35 |
| Incident cerebrovascular event | 45 (8.2) | 9 (6.5) | 16 (11.9) | 8 (5.9) | 12 (8.5) | 0.27 |
| Incident PAD event | 26 (4.7) | 7 (5.0) | 8 (5.9) | 5 (3.7) | 6 (4.2) | 0.83 |
| Any of the incident cardiovascular events above | 137 (24.8) | 38 (27.3) | 34 (25.2) | 27 (19.9) | 38 (26.8) | 0.46 |
| Mortality outcomes | ||||||
| Cardiovascular death | 49 (9.0) | 13 (9.4) | 10 (7.5) | 17 (12.6) | 9 (6.5) | 0.31 |
| Death from any cause | 152 (27.9) | 37 (26.8) | 39 (29.3) | 39 (28.9) | 37 (26.6) | 0.94 |
Abbreviations: CHD, coronary heart disease; PAD, peripheral arterial disease; T, total testosterone.
Footnotes: aP values are from a chi-squared test for homogeneity.