Table 7-3.

Predominantly CK7+/CK20+

TUMOR	CK7+ CK20+	CK7+ CK20–	CK7– CK20+	CK7– CK20–	34β E12	CAM 5.2	CK 5/6	EMA	BER- EP4	CEA m	CEA p	TTF-1	P63	WT-1	S100	CHRO	HEP	OTHER
Cholangiocarcinoma	High	Low	Low	neg	High	POS	Low	POS	POS	High	POS	neg	Low				rare
Transitional cell carcinoma	POS	Low	neg	neg	Mod	POS	High	POS		Mod	Mod	neg	High	neg	neg	neg	neg
Pancreas	High	Low	Low	neg		POS	Low	POS	POS	High	POS	neg	Mod		neg	neg	Low	DPC4 lost in 55%
Ovarian mucinous	POS	Low	neg	neg		POS	neg	POS		Mod	Low			neg			Low
Esophageal adenocarcinoma	POS	neg	neg	neg								neg	Low	neg			Mod