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. 2009 May 15:183–272. doi: 10.1016/B978-0-443-07271-0.50006-9

Table 4.11.

Second neurological episode in multiple sclerosis: data from the main series of the long-term course and prognosis in multiple sclerosis

Study Time from the relapsing– remitting onset of multiple sclerosis to the second neurological episode (years) Factors predictive of time from the relapsing– remitting onset of multiple sclerosis to the second neurological episode
Long-term natural history series with cross-sectional and/or some longitudinal assessment
McAlpine and Compston 1952

  • Observed data

  • 2 (median)

 Not available
Myhr et al 2001

  • Observed data

  • 3.5 ± 0.2 (mean ± SEM)

 Not available
Long-term natural history cohorts with longitudinal follow-up
Lyon, France, multiple sclerosis cohort
Confavreux 1977 Observed data Observed data
Confavreux et al 1980 2 (median)

  • Gender: none

  • Age at onset of multiple sclerosis: none

  • Overall course of multiple sclerosis (relapsing–remitting vs. secondary progressive): none
Confavreux et al 2000; 2003

  • Life table analysis

  • 2 (median)

 Not available
Gothenburg, Sweden, multiple sclerosis cohort
Broman et al 1981 Life table analysis Life table analysis
Runmarker and Andersen 1993 Cases with a ‘clinically isolated Cox regression analysis
Eriksson et al 2003

  • syndrome’ at onset:

  • 3.25 ± 0.64 (median ± SEM)

  • Cases with a ‘clinically isolated syndrome’ at onset:

  • Gender/age at onset: none

  • Initial symptoms: optic neuritis/sensory, longer; long tracts, shorter; monofocality, none

  • Recovery from first episode: none

SD = standard deviation.

SEM = standard error of the mean.