Table 4.16.

Kaplan–Meier estimates of the time (years) from onset of multiple sclerosis to the assignment of disability DSS scores, among the 1844 patients in the Lyon, France, multiple sclerosis cohort.

Time (years)	0	0.5	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	20	25	30	35	40
Patients (%) free of
DSS 4	100	82	79	73	69	65	61	58	56	52	49	47	44	41	39	37	35	26	17	13	6	0
DSS 6	100	99	98	96	92	89	86	83	80	77	74	72	70	67	63	62	59	50	42	36	28	23
DSS 7	100	100	100	99	98	97	95	93	91	89	87	85	83	81	79	77	75	65	55	50	43	37

	Median time (years)	Patients (%) who did not reach the end pointa
Time to DSS 4	8.4 [95% CI 7.6–9.2]	44
Time to DSS 6	20.1 [95% CI 18.2–22.0]	68
Time to DSS 7	29.9 [95% CI 25.8–34.1]	79

^aData on patients who did not reach the end point and were censored at the time of the last clinic visit.

Adapted from Confavreux et al (2000; 2003)

© 2006