. 2009 May 15:183–272. doi: 10.1016/B978-0-443-07271-0.50006-9

Table 4.17.

Kaplan–Meier estimates of the time (years) from onset of multiple sclerosis to the assignment of disability status scale scores among the 1844 patients from the Lyon multiple sclerosis cohort. Influence of the initial course of the disease. A: estimates for the 1562 patients with a relapsing–remitting initial course of multiple sclerosis (see Figure 4.15A). B: estimates for the 282 patients with a progressive initial course of multiple sclerosis (see Figure 4.15B).

A: Patients with a relapsing–remitting initial course of multiple sclerosis (n = 1562)
Time (years)	0	0.5	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
Patients (%) free of
DSS 4	100	91	89	84	79	75	71	68	65	61	58	56	52	49	46	44	42	40	38	35	34	31

DSS 6	100	99	98	97	95	93	91	89	86	84	82	80	77	75	71	69	66	63	62	60	59	57

DSS 7	100	100	100	99	99	97	96	95	94	92	90	88	87	85	83	82	80	79	76	73	72	71

	Median time (years)	Patients (%) who did not reach the end point^a
Time to DSS 4	11.4 [95% CI 10.5–12.3]	52

Time to DSS 6	23.1 [95% CI 20.1–26.1	73

Time to DSS 7	33.1 [95% CI 29.2–37.0	82

B: Patients with a progressive initial course of multiple sclerosis (n = 282)
Time (years)	0	0.5	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
Patients (%) free of
DSS 4	100	32	28	16	12	9	8	6	5	4	3	2	1	1	1	1	0	0	0	0	0	0

DSS 6	100	98	96	91	82	73	63	57	51	43	37	32	30	27	26	26	25	23	22	21	19	17

DSS 7	100	100	99	98	95	93	89	83	79	75	69	67	61	57	52	48	45	40	40	33	31	28

	Median time (years)	Patients (%) who did not reach the end point^a
Time to DSS 4	0.0	4

Time to DSS 6	7.1 [95% CI 6.3–7.9]	40

Time to DSS 7	13.4 [95% CI 11.0–15.9]	64

DSS = Disability Status Scale.

Data on patients who did not reach the end point were censored at the time of the last clinic visit.

Adapted from Confavreux et al (2000, 2003)